Table 1:

Summary of demographics

	Overall	ART Naïve PLWH (Naïve)	ART Experienced PLWH (Exp)	Healthy controls (HC)	p-value
					Naïve vs Exp	Naïve vs HC	Exp vs HC
	(N=148)	(N=67)	(N=39)	(N=42)
Arm
Rural	75 (50.7%)	34 (50.7%)	19 (48.7%)	22 (52.4%)	NS	NS	NS
Urban	73 (49.3%)	33 (49.3%)	20 (51.3%)	20 (47.6%)
Sex
Female	85 (57.4%)	39 (58.2%)	23 (59.0%)	23 (54.8%)	NS	NS	NS
Male	63 (42.6%)	28 (41.8%)	16 (41.0%)	19 (45.2%)
Age (years)	37 [29–44]	35 [27–39]	45 [42–51]	36 [28–41]	***	NS	***
BMI (kg/m2)	22 [20–24]	23 [20–24]	22 [19–24]	23 [21–26]	NS	NS	*
BMI Cathegory
Severe Thinness <16.0	3 (2.03%)	1 (1.49%)	2 (5.13%)	0
Moderate Thinness <17.0	1 (0.68%)	0	0	1 (2.38%)
Mild Thinness <18.5	9 (6.08%)	3 (4.48%)	5 (12.8%)	1 (2.38%)	NS	NS	NS
Normal 18.5–24.9	105 (70.9%)	51 (76.1%)	26 (66.7%)	28 (66.7%)
Overweight ≥25.0	25 (16.9%)	10 (14.9%)	5 (12.8%)	10 (23.8%)
Obese ≥30.0	5 (3.38%)	2 (2.99%)	1 (2.56%)	2 (4.76%)
CD4 T cells count (cells/μL)	300 [150–430]	260 [120–350]	390 [230–550]	NA [NA-NA]	**	NA	NA
CD4 T cells (%)	36 [19–49]	22 [12–36]	36 [20–45]	56 [48–63]	**	***	***
CD4/CD8 T cell ratio	0.70 [0.32–1.2]	0.39 [0.18–0.68]	0.67 [0.34–0.97]	1.7 [1.1–2.1]	**	***	***
ART exposure (months)	NA [NA-NA]	0	89 [69–114]	NA [NA-NA]	NA	NA	NA
Co-trimoxazole exposure (months)	0 [0–14]	0.030 [0–0.22]	84 [60–99]	0 [0–0]	***	***	***
Viral Load (copies/mL)	4194 [19–48992]	26491 [3824–71217]	0 [0–19]	NA [NA-NA]	****	NA	NA
Viral Load Outcome
Virologic failure	21 (14.2%)	15 (22.4%)	6 (15.4%)	0 (0%)	NS	***	**
Both Visits
Yes	133 (89.9%)	59 (88.1%)	37 (94.9%)	37 (88.1%)	NS	NS	NS
No	15 (10.1%)	8 (11.9%)	2 (5.1%)	5 (11.9%)