Table 1: Newly identified trait-locus pairs for complex brain imaging traits in sex-agnostic analysis.
The trait-locus pairs were compared with results on the NHGRI-EBI GWAS catalog (2023.06). The raw p-values are adjusted by using wild bootstrap. The physical locations of loci are according to GRCh37 release 13.
| Trait | UniqID | RsID | p-Value | p-Value (adj) | Start | End | Region |
|---|---|---|---|---|---|---|---|
|
| |||||||
| BV of cerebrospinal fluid | 23:38009121:A:G | rs35318931 | 6.71E-12 | 3.82E-10 | 37933437 | 38017972 | Xp11.4 |
| BV of thalamus proper (left) | 23:28140326:A:G | rs2131673 | 4.69E-14 | 4.51E-12 | 28033828 | 28284470 | Xp21.3 |
| BV of thalamus proper (right) | 23:28140326:A:G | rs2131673 | 1.99E-13 | 2.8E-11 | 28033828 | 28284470 | Xp21.3 |
| BV of ventral DC (right) | 23:68377485:A:G | rs2361468 | 4.22E-11 | 4.74E-08 | 68354618 | 68384580 | Xq13.1 |
| Total SA (left) | 23:154740180:A:G | rs76536573 | 3.09E-13 | 4.85E-11 | 153732991 | 154949953 | Xq28 |
| Total SA (right) | 23:154678628:C:G | rs28880039 | 1.13E-11 | 4.32E-09 | 153732991 | 154949953 | Xq28 |
| SA of supramarginal (left) | 23:136505579:C:T | rs2743914 | 8.02E-15 | 4.82E-13 | 136471150 | 137073809 | Xq26.3 |
| SA of supramarginal (right) | 23:136500146:A:G | rs2840674 | 4.65E-12 | 1.43E-09 | 136450688 | 136841801 | Xq26.3 |
| PTR (AD PC3) | 23:154740180:A:G | rs76536573 | 5.57E-13 | 7.18E-13 | 154379088 | 154972517 | Xq28 |
| SCR (AD PC1) | 23:152590165:C:G | rs5970442 | 1.41E-12 | 3.23E-10 | 152576561 | 152656246 | Xq28 |
| BCC (RD PC2) | 23:39464147:C:T | rs7888246 | 4.66E-12 | 1.43E-09 | 39383773 | 39494923 | Xp11.4 |
| PLIC (MO PC4) | 23:150542930:G:T | rs201850695 | 1.1E-13 | 5.5E-14 | 150497978 | 150614462 | Xq28 |
| PLIC (MO PC5) | 23:150514840:C:T | rs5924909 | 2.75E-10 | 1.07E-08 | 150514840 | 150614316 | Xq28 |