Table 3:
En masse test of concordance of effect directions between genetic variants identified for ANX (condFDR) and corresponding variants in independent GWAS of anxiety disorders
| CondFDR Phenotype pairs | ANX-loci (n) | SNPs (n) in the replication dataset | SNPs (n) with concordant effects | p-value* |
|---|---|---|---|---|
|
| ||||
| ANX | MD | 83 | 79 | 69 | 2.77e-12 |
| ANX | BIP | 41 | 38 | 34 | 3.02e-07 |
| ANX | SCZ | 70 | 66 | 54 | 8.47e-08 |
| ANX | ADHD | 59 | 59 | 47 | 2.56e-06 |
GWAS: Genome-wide association study, SNP: Single nucleotide polymorphism, FDR: False discovery rate, ANX: Anxiety symptoms, MD: Major depression, BIP: Bipolar disorder, SCZ: Schizophrenia, ADHD: Attention deficit hyperactivity disorder,
*
one-sided binomial test