Table 3:
Genetic risk loci for anxiety identified from meta-analysis of genome-wide association studies.
| CHR: Position1 | SNP | A1 | A2 | Gene2 | Function | Beta (SE) | p-value |
|---|---|---|---|---|---|---|---|
|
| |||||||
| 2:63893589 | rs17619012 | T | G | WDPCP | intergenic | −0.023 (0.0039) | 2.80E-09 |
| 2:233005775 | rs3103257 | A | G | NPPC | intronic | 0.020 (0.0036) | 3.23E-08 |
| 3:18795765 | rs7622860 | A | C | SATB1 | ncRNA_intronic | 0.023 (0.0036) | 8.09E-11 |
| 7: 113901132 | rs6961970 | A | C | FOXP2 | intronic | 0.021 (0.0038) | 4.40E-08 |
| 9: 98273305 | rs145965565 | T | G | PTCH1 | intronic | −0.032 (0.0056) | 8.99E-09 |
| 10:75496130 | rs12253482 | A | G | CAMK2G | ncRNA_intronic | 0.018 (0.0033) | 4.09E-08 |
| 10:124012277 | rs143042901 | A | G | PLEKHA1 | intronic | −0.050 (0.0092) | 4.98E-08 |
| 13:60362163 | rs11841641 | T | C | DIAPH3 | intronic | 0.040 (0.007) | 1.67E-08 |
| 14:42075952 | rs1111179 | T | G | LRFN5 | upstream | −0.018 (0.0032) | 4.90E-08 |
| 17:43911716 | rs242949 | T | G | MAPT | intronic | −0.019 (0.0033) | 1.37E-08 |
| 20:62714171 | rs539856305 | T | G | OPRL1 | intronic | 0.034 (0.0057) | 2.02E-09 |
1
Based on genome build hg19.
2
Genes annotations were based on the highest overall score in OpenTargets.
CHR Chromosome; A1 Effect allele; A2 Other allele; SNP single nucleotide polymorphism; SE Standard error.
The rows with novel loci are shaded in grey.