Table 3.

Aggregates of rare variants in noncoding sets with AD

Group**	Gene name	Chr	Category	# variants	STAAR-0 p-value*
Pooled samples	TOMM40	19	Promoter (DHS)	134	7.2×l0−8
Pooled samples	ELMSAN1	14	Enhancer(DHS)	1133	1.8×l0−9
Pooled samples	EIF2B2	14	Enhancer (DHS)	1240	3.2×l0−8
Pooled samples	MIR4505	14	ncRNA	7	2.4×10−11
HIS	PTGR2	14	Promoter (CAGE and DHS)	7	8.85×10−12
HIS	ELMSAN1	14	Enhancer(DHS)	366	3.1×10−11
HIS	PTGR2	14	Enhancer (CAGE)	153	5.9×10−11
HIS	ACOT6	14	Enhancer(DHS)	33	4.2×10−10
HIS	ELMSAN1	14	Promoter (DHS)	55	8.8×10−10
HIS	ACOT4	14	Promoter (CAGE)	6	9.3×10−10
HIS	ACOT4	14	Enhancer (CAGE)	9	9.8×10−10

^*Where more than one rare noncoding aggregate was significant for a linked gene, the most significant p-value is reported for each category type.