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[Preprint]. 2023 Sep 2:2023.09.01.23294951. [Version 1] doi: 10.1101/2023.09.01.23294951

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Figure 3: — CVD-associated SNPs alter NKX2–5 in vitro binding. A) DelstaSVM score distribution of the 9,309 CVD-associated SNPs. B) Representative EMSA gel for rs59310144 reference (Ref) and alternate (Alt) alleles. C) Binding curves for reference (Ref) and variant (Alt) alleles of rs59310144 (top), rs6715570 (middle), and rs61872084 (bottom). Experiments were performed in triplicates and binding curves show average bound fractio (X) and error bars are standard error. D) Cardiac tissue eQTL analysis of RNASEH2B (top), BARD1 (middle), and METTL10 (bottom) expressed in heart atrial appendage or left ventricle when rs59310144, rs6715570, and rs61872084 occur, respectively.