Table 1.
Traits with their source GWAS. The ‘Ref’ column includes the reference as numbered in the bibliography. For binary traits, sample prevalence (prev) is given. The SNP-based heritability (h2SNP) is given as provided in the source article*.
| Trait group | Ref | Phenotype | Name in plots | Contains UKB | N | Sample prev | h2SNP | Consortia | Year | doi |
|---|---|---|---|---|---|---|---|---|---|---|
| CVD | 53 | Atrial fibrillation | Atrial fibrillation | yes | 1,030,836 | 0.06 | 0.42 | AFGen, Broad AF | 2018 | 10.1038/s41588-018-0133-9 |
| CVD | 54 | Coronary artery disease | Coronary artery disease | yes | 1,165,720 | 0.16 | 0.16 | CARDIoGRA MplusC4D | 2022 | 10.1038/s41588-022-01233-6 |
| CVD | 55 | Heart Failure | Heart Failure | yes | 977,323 | 0.05 | 0.09 | HERMES | 2020 | 10.1038/s41467-019-13690-5 |
| CVD | 56 | Stroke | Stroke | yes | 1,308,460 | 0.05 | 0.01 | GIGASTROKE | 2022 | 10.1038/s41586-022-05165-3 |
| CVD | 57 | Peripheral artery disease | Peripheral artery disease | yes | 449,548 | 0.03 | 0.55 | MVP/UKB | 2021 | 10.1161/CIRCGEN.119.002862 |
| MDD | 4 | Major depressive disorder | MDD | yes | 1,035,760 | 0.28 | 0.07 | iPSCYH/ PGC | 2022 | 10.1038/s41591-023-02352-1 |
| MDD symptoms | 50 | Anhedonia | Anhedonia | yes | 117,757 | NA | 0.05* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Depressed mood | Depressed | yes | 117,656 | NA | 0.04* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Sleep | Sleep | yes | 117,822 | NA | 0.06* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Tiredness | Tired | yes | 117,828 | NA | 0.07* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Changes in appetite | Appetite | yes | 117,907 | NA | 0.05* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Feelings of inadequacy | Inadequacy | yes | 117,502 | NA | 0.03* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Concentration problems | Concentration | yes | 117,899 | NA | 0.05* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Psychomotor changes | Psychomotor | yes | 117,868 | NA | 0.02* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| MDD symptoms | 50 | Suicidality | Suicidal | yes | 117,177 | NA | 0.02* | (UKB) | NA | Neale Lab UK Biobank. https://www.nealelab.is/uk-biobank/ |
| Childhood maltreatment | 58 | Childhood Maltreatment | Childhood maltreatment | yes | 150,290 | NA | 0.06 | PGC | 2020 | 10.1038/s41398-020-0706-0 |
| Risk factors: psychosocial | 59 | Educational attainment | Educational attainment | yes | 766,345 | NA | 0.12 | SSGAC | 2018 | 10.1038/s41588-018-0147-3 |
| Risk factors: psychosocial | 60 | Ever regular smoker | Smoking | no | 848,460 | 0.46 | 0.08 | GSCAN | 2019 | 10.1038/s41588-018-0307-5 |
| Risk factors: psychosocial | 61 | Physical activity (accelerometer) | Physical activity | yes | 91,105 | NA | 0.21 | (UKB) | 2018 | 10.1038/s41467-018-07743-4 |
| Risk factors: psychosocial | 62 | Self-reported activity | Exercise | yes | 703,901 | 0.47 | 0.04 0.08 | NA | 2022 | 10.1038/s41588-022-01165-1 |
| Risk factors: psychosocial | 61 | Sleep duration | Sleep duration | yes | 91,105 | NA | 0.19 | (UKB) | 2018 | 10.1038/s41467-018-07743-4 |
| Risk factors: psychosocial | 63 | Loneliness | Loneliness | yes | 452,302 | NA | 0.04 | (UKB) | 2018 | 10.1038/s41467-018-04930-1 |
| Risk factors: metabolic | 64 | Body Mass Index | BMI | yes | 795,640 | NA | 0.22 | GIANT | 2018 | 10.1093/hmg/ddy271 |
| Risk factors: metabolic | 65 | High-density lipoprotein | High-density lipo. | yes | 1,244,580 | NA | 0.11* | GLGC | 2021 | 10.1038/s41586-021-04064-3 |
| Risk factors: metabolic | 65 | Non-high-density lipoprotein | Non-high-density lipo. | yes | 926,571 | NA | 0.08* | GLGC | 2021 | 10.1038/s41586-021-04064-3 |
| Risk factors: metabolic | 65 | Low-density lipoprotein | Low-density lipo. | yes | 1,231,289 | NA | 0.07* | GLGC | 2021 | 10.1038/s41586-021-04064-3 |
| Risk factors: metabolic | 65 | Total cholesterol | Total cholesterol | yes | 1,253,277 | NA | 0.08* | GLGC | 2021 | 10.1038/s41586-021-04064-3 |
| Risk factors: metabolic | 65 | Triglycerides | Triglycerides | yes | 1,320,016 | NA | 0.10* | GLGC | 2021 | 10.1038/s41586-021-04064-3 |
| Risk factors: metabolic | 66 | Type II diabetes | Type II diabetes | yes | 80,154 | 853,816 | 0.05* | DIAMANTE | 2022 | 10.1038/s41588-022-01058-3 |
| Risk factors: inflammation | 67 | Interleukin 6 | IL6 | no | 52,654 | NA | 0.04 | CHARGE | 2021 | 10.1093/hmg/ddab023 |
| Risk factors: inflammation | 68 | C-reactive protein | C-reactive protein | yes | 575,531 | NA | 0.13 | CHARGE | 2022 | 10.1038/s41467-022-29650-5 |
| Risk factors: blood pressure | 69 | Diastolic Blood Pressure | Diastolic Blood Press. | yes | 757,601 | NA | 0.21 | UKB, ICBP | 2018 | 10.1038/s41588-018-0205-x |
| Risk factors: blood pressure | 69 | Pulse Pressure | Pulse Pressure | yes | 745,820 | NA | 0.19 | UKB, ICBP | 2018 | 10.1038/s41588-018-0205-x |
| Risk factors: blood pressure | 69 | Systolic Blood Pressure | Systolic Blood Press. | yes | 745,820 | NA | 0.21 | UKB, ICBP | 2018 | 10.1038/s41588-018-0205-x |
When it was not reported in the source article, we include the observed scale h2sNP estimated by LDSC for the genetic correlation analyses. Note that different studies have used different methods to derive h2sNP.
UKB=UK Biobank; sample prev=sample prevalence; CVD=cardiovascular disease; CARDIoGRAMplusC4D=(Coronary ARtery Disease Genome wide Replication and Meta-analysis (CARDIoGRAM) plus The Coronary Artery Disease (C4D) Genetics); HERMES=Heart failure Molecular Epidemiology for Therapeutic targets; MVP=the Million Veteran Program; MDD=major depressive disorder; PGC=Psychiatric Genomics Consortium; SSGAC=Social Science Genetic Association Consortium; GSCAN=GWAS & Sequencing Consortium of Alcohol and Nicotine use; GiANT=The Genetic investigation of Anthropometric Traits consortium; GLGC=Global Lipids Genetics Consortium; DiAMANTE=Diabetes Meta-Analysis of Trans-Ethnic association studies; inflamm=inflammation; CHARGE=Cohorts for Heart and Aging Research in Genomic Epidemiology; blood pres=blood pressure; iCBP=international Consortium for Blood Pressure.