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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Clin Obstet Gynecol. 2023 Jul 24;66(3):568–578. doi: 10.1097/GRF.0000000000000804

Table 3.

PPV and NPV rates of a high-risk NIPT for SCA incorporating varied prevalence rates (modified from Shear 2020[22])

Estimated prevalence (per 1000) PPV 95% range NPV 95% Confidence interval range
45,X 0.30 – 1.8 4.8 – 22.9% 2.2 – 57.6% 99.9–100% 99.9–100%
47,XXX 0.54 – 1.8 32.4 – 61.6% 15.3 – 95.4% same same
47,XXY 0.91 – 2.4 94.1 – 97.7% 58.2 – 100% same same
47,XYY 0.32 – 0.75 100% 58.5 – 76.5% same same