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. 2023 Aug 11;42(37):2737–2750. doi: 10.1038/s41388-023-02781-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representative images after Giemsa staining of BMDM and PM treated by normal medium or tumor-CM. b CD206 and IL-10 expression on BMDMs and PMs treated by normal medium or tumor-CM were analyzed by flow cytometry and cytometric beads array (CBA), respectively. CBA was conducted to measure expression level of IL-6, MCP-1, IL-10 and TNF in the supernatant of the TC-Mφ from BMDMs (c) and PMs (d). e mRNA expression of JMJD6 was detected by qPCR in PMs and BMDMs stimulated by tumor-CM or not. f mRNA expression of JMJD6 was detected in TC-Mφ from BMDMs and PMs of WT or Jmjd6^+/− mice. g Flow analysis reveals the expression of M2 biomarkers CD206 in BMDMs and PMs stimulated by tumor-CM or not. h The secretion level of IL-10 in BMDMs and PMs stimulated by tumor-CM or not was detected by CBA assays. i BMDMs from WT or Jmjd6^+/− mice were cultured in Tumor-CM for 48 h, and the secretion level of IL-6, MCP-1, and TNF was detected by CBA. Data represent mean ± SD (n = 3). ns: no significant difference, *P < 0.05; **P < 0.01; ***P < 0.001.