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. 2023 Aug 11;42(37):2737–2750. doi: 10.1038/s41388-023-02781-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic diagram of anti-PD-1 treatment on WT and Jmjd6^+/− mice B16F10 lung metastasis tumor model. b Lung photo at the end of the experiment. c Statistical results of the number of lung tumor nodules in mice. d Representative images of mouse lungs H&E staining. e The infiltration of M2-like TAMs (CD206⁺ MHC-II^-), detected by flow cytometry. f The infiltration of CD3⁺ total T cells, detected by flow cytometry. g The infiltration of CD8⁺ GZMB⁺ T cells, detected by flow cytometry. h Illustration of mechanism for JMJD6/STAT3/IL-10 axis. Data represent mean ± SD (n = 5). ns: no significant difference, *P < 0.05, **P < 0.01, ***P < 0.001.