Table 1.

Patient time contributing to CYP2D6 substrate cohorts

CYP2D6 substratea	No. of patients	Time before overlapping dispensing (person-months)	Time with overlapping dispensing (person-months)	Overlapping time (%)
Tramadol	10,200	10,110	12,195	46.1
Donepezil	1467	9799	9944	41.3
Amitriptyline/nortriptyline	4068	18,638	18,101	38.6
Aripiprazole	1675	9589	8321	38.4
Hydrocodone	17,998	20,346	17,184	36.5
Tamsulosin	8029	51,734	39,259	35.2
Citalopram/escitalopram	8813	70,593	48,003	32.2
Duloxetine/venlafaxine	8991	81,973	55,202	31.4
Metoprolol/carvedilol	10,274	106,558	64,591	29.8
Tolterodine	4622	23,902	9385	22.6

CYP cytochrome P450

^aPresented by decreasing percentage of overlapping time