Table 2.

Gross toxicity scale [17, 18]

Sign	Expression, scorea
	0	1	2	3	4
General appearance	Normal		Unnatural posture/hunched pose	Emaciation
Hypo/hyperkinesia	Absent	Decrease/increase activity	Drowsiness/aggression	Unresponsive to extraneous activity and provocation
Movement activity	Normal	Dysbasia/circling	tremor	Convulsions, limb paralysis
Respiration alterations	Absent	Deep/heavy/rapid/shallow			Respiratory arrest
Skin/coat injuries	Absent	Redness	Wounds	Abscess	Necrosis
Piloerection	Absent	Present
Eyes conditions alterations	Absent	Pale/clouded/ tearing	Sunken/inflamed/half-closed	Closed eyes, do not open on touch
Exudation	Absent		ptyalism/nasal Exudation
Defecation changes	Absent	Abdomen abnormally enlarged/ loose stool	Constipation	Diarrhea	Defecation with blood
Oedema/ alterations including the site of administration	Absent	Oedema/other changes at the site of administration	Not at the site of administration
Body temperature	Normal		Increased/decreased
Vocalization	Absent	Occasional	Consistent

^aDeath of animal is considered to be equal 10