. 2023 Sep 8;18(1):111. doi: 10.1186/s11671-023-03891-9

Table 3.

Histopathology signs [18]

	Kidney
Glomerulus state	Glomerulus shrinkage/capsule space dilation
Tubular state	Epithelial cell flattening, epithelial cell vacuolation, epithelial cell desquamation/loss, loss of brush border, tubular atrophy, tubular dilation
Inflammation/necrosis signs	Eosinophilic cast deposition, tubular epithelial necrosis^a, interstitial nephritis, glomerulonephritis, hemorrhages^a, vessel dilation
Abnormal regeneration	Connective tissue accumulation, tubular hyperplasia, tubular basophilia

	Liver
Hepatocytes alteration	Lipid dystrophy, ground-glass hepatocytes, eosinophilic alteration, basophilic alteration
Regeneration	Hepatocellular hypertrophy, polyploid cells
Inflammation/necrosis signs	Vessel congestion/dilation, blood sinusoids dilation, lympho-histiocytes accumulation loci, Kupffer cell diffuse accumulation, necrotic loci^a, apoptotic loci^a
Connective tissue accumulation

	Spleen
Hypo/hyperplasia	Lymphoid hypoplasia as reduced white pulp, lymphoid atrophy, red pulp hyperplasia, white pulp hyperplasia, megakaryocytosis, marginal zone hyperplasia
Inflammation/necrosis signs	Necrosis^a, hemorrhages^a
Accumulations	Lipid accumulation, pigmentation, connective tissue accumulation

Trait intensity score: “0”—not observed or less than 10%; “+”—less than 50%; “++ ”—less than 80%; “+ + + ”—more than 80% of field of view/number if counted

^a“0”—not observed; “+”—small occasional, “++”—small frequent, “+++”—large occasional, “++++”—large frequent