TABLE 1.
Overview of all relevant hematological and biochemical parameters in the peripheral blood.
| Normal range | Day 0 | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 a | Day 6 | Day 7 | Day 13 | Day 20 | Ambulatory | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hematology | ||||||||||||
| Hemoglobin (g/dL) | 13.3–17.1 | 14.5 | 12.9 | 8.4 | 7.2 | 7.3 | 7.0 | 6.7 | 7.9 | 7.2 | 9.1 | 14.5 |
| Platelets (109/µL) | 166–396 | 208 | 140 | 32 | 35 | 52 | 31 | 36 | 83 | 262 | 351 | 206 |
| Schistocytes (%) | <1 | 6 | 7 | 5 | 3 | 3 | <1 | |||||
| Plasma hemoglobin mg/L) | 10–40 | 559 | ||||||||||
| Haptoglobin (g/L) | 0.40–2.80 | 0.04 | 0.11 | 0.52 | 2.65 | 1.57 | ||||||
| Hemostasis | ||||||||||||
| APTT (s) | 23–31 | 24.6 | 22.9 | 28.2 | 26.3 | 23.6 | 22.2 | 22.8 | <20.0 | 25.6 | 20.3 | 23.4 |
| PT (%) | 78–123 | 81 | 85 | 100 | 117 | 121 | 108 | 97 | 85 | 111 | 106 | 120 |
| INR | 0.9–1.2 | 1.10 | 1.08 | 1.02 | 0.95 | 0.94 | 0.98 | 1.03 | 1.08 | 0.96 | 0.98 | 0.93 |
| Fibrinogen (mg/dL) | 170–420 | 157 | 182 | 300 | 473 | 527 | 589 | 300 | 207 | 585 | 295 | |
| ADAMTS‐13 activity (%) | 61–131 | 32 | 67 | |||||||||
| Hemostasis | ||||||||||||
| Serum creatinine(mg/dL) | 0.60–1.10 | 1.01 | 1.1 | 2.65 | 3.84 | 5.51 | 6.89 | 6.40 | 6.01 | 2.18 | 0.91 | 0.78 |
| e‐GFR CKD‐EPI (mL/min/1.73 m2) | >60 | 80 | 72 | 25 | 16 | 10 | 8 | 9 | 9 | 32 | 91 | 97 |
| CRP (mg/L) | <10 | <4 | 69 | 202 | 222 | 190 | 179 | 55.6 | 15.9 | 184 | 38 | |
| LDH (E/L) | 120–246 | 434 | 466 | 1371 | 2612 | 3195 | 3421 | 831 | 398 | 301 | 227 | 171 |
| CK (E/L) | 46–171 | 277 | 284 | 502 | 937 | 991 | 1258 | 305 | 80 | 50 | 34 | 37 |
| Total bilirubin (mg/dL) | 0.30–1.20 | 0.51 | 1.3 | 3.8 | 4.8 | 4.0 | 4.7 | 2.7 | 1.9 | 0.65 | 0.22 | 0.29 |
| Unconjugated bilirubin (mg/dL) | 0.10–1.20 | 0.38 | 0.91 | 3.4 | 4.3 | 2.9 | 3 | 1.7 | 1.3 | 0.36 | 0.11 | 0.29 |
| ANF | Negative | Negative | ||||||||||
| Anticardiolipin | ||||||||||||
| IgG (U/mL) | <10 | 0.7 | ||||||||||
| IgM (U/mL) | <10 | 2.4 | ||||||||||
| Serum electrophoresis | Normal pattern | Abnormal peak in β2 fraction | Normal pattern | |||||||||
| Albumin (g/L) | 31.8–51.2 | 26.2 | 42.4 | |||||||||
| Alpha‐1 (g/L) | 1.7–4.0 | 5.8 | 2.9 | |||||||||
| Alpha‐2 (g/L) | 4.0–9.7 | 5.1 | 7.7 | |||||||||
| Beta‐1 (g/L) | 2.7–5.9 | 2.3 | 3.9 | |||||||||
| Beta‐2 (g/L) | 1.8–5.3 | 6.0 | 3.2 | |||||||||
| Gamma (g/L) | 6.3–15.4 | 4.6 | 9.0 | |||||||||
| Immunofixation | Negative | Negative | ||||||||||
| Complement | ||||||||||||
| Total hemolytic complement (%) | 69–129% | 120 | ||||||||||
| C3 (g/L) | 0.9–1.7 | 1.16 | ||||||||||
| C3d (g/L) | <0.0075 | 0.0074 | ||||||||||
| C4 (g/L) | 0.12–0.36 | 0.26 | ||||||||||
| CMV | ||||||||||||
| IgG (E/mL) | <0.5 | 2.7 | ||||||||||
| IgM | Negative | Negative | ||||||||||
| HIV serology | Negative | Negative | ||||||||||
| Vitamine B12 (ng/L) | 211–911 | 484 |
Abbreviations: ADAMTS13, a Disintegrin and Metalloproteinase with Thrombospondin motifs 13; ANF, antinucleoid factor; APTT, activated partial prothromboplastin time; BUN, blood urea nitrogen; CK, Creatinine kinase; CMV, cytomegalovirus; Cr, creatinine; CRP, C reactive protein; e‐GFR, estimated glomerular filtration rate; HIV, human immunodeficiency virus; INR, international normalized ratio; LDH, lactate dehydrogenase; PT, prothrombin time.
a
Plasmapheresis was started on day 5.