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. 2023 Jul 10;129(6):904–916. doi: 10.1038/s41416-023-02326-7

Fig. 1. Emerging targets for rational combinations with PARP inhibitors.

Fig. 1

The figure displays various pathways that modulate response to DNA damage and are identified as key targets in combination with PARP inhibitors. The receptor tyrosine kinase cascade mediated by the EGFR, VEGF and c-MET receptors with downstream effectors such as the RAS/MEK and PI3K/AKT pathways are hypothesised to increase homologous repair capacity. Pathways and proteins involved in cell cycle progression such as ATR and WEE1 play an integral role in response to DNA damage in addition to emerging targets USP1 and POLQ. DNA damage mediated by PARP inhibitors is hypothesised to increase T-cell recruitment via activation of the cGAS-STING pathway.