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. 2023 Jun 8;23(5):158–162. doi: 10.1016/j.ipej.2023.06.001

Fig. 3.

Fig. 3

Pathophysiology of RyR2 mutation at binding site of FKBP12.6 leading to aberrant opening of the channel in diastole.

Figure adapted from:

• Wleklinski MJ, Kannankeril PJ, Knollmann BC. Molecular and tissue mechanisms of catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2020; 598(14):2817–2834. https://doi.org/10.1113/JP276757

• Tong M, Jiang Y. FK506-Binding Proteins and Their Diverse Functions. Curr Mol Pharmacol. 2015; 9(1):48–65. https://doi.org/10.2174/1874467208666150519113541.