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. 2022 Nov 9;51:161–179. doi: 10.1016/j.jare.2022.10.014

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© 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Metrnl activates the ULK1/autophagy signaling in cardiomyocytes. (A) Effects of Metrnl on HG-induced downregulation of phosphorylated ULK1. (B) Effects of Metrnl shRNA on HG-induced downregulation of phosphorylated ULK1. (C) Effects of Metrnl on the mRNA levels of autophagy-related genes. (D) Effects of Metrnl on the formation of autophagosome as assessed by LC3 dots. Scale bar = 20 μm. (E) Effects of Metrnl on the protein expressions of p62 and LC3. (F) Effects of Metrnl shRNA on the formation of autophagosome as assessed by LC3 dots. Scale bar = 20 μm. (G) Effects of Metrnl shRNA on the protein expressions of p62 and LC3. n = 4. *P < 0.05 versus NG, Con, Con shRNA, †P < 0.05 versus HG or HG + Con shRNA.