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. 2022 Nov 9;51:161–179. doi: 10.1016/j.jare.2022.10.014

Fig. 8.

Fig. 8

ULK1 phosphorylation is required for Metrnl to inactivate the cGAS/STING signaling in cardiomyocytes. (A) Effects of Metrnl on cGAS, phosphorylated STING, and total STING. (B) Effects of Metrnl shRNA on cGAS, phosphorylated STING, and total STING. (C) Effects of Metrnl (upper) or Metrnl shRNA (lower) on STING in mitochondria. (D) Effects of Con siRNA and ULK1 siRNA on ULK1 protein. (E) Silencing of ULK1 abolished the inhibitory effects of Metrnl on cGAS, phosphorylated STING, total STING and STING in mitochondria. n = 4. *P < 0.05 versus NG or Con shRNA, †P < 0.05 versus HG + Con shRNA or HG, ‡ P < 0.05 versus HG + Metrnl + Con siRNA.