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. 2023 Jul 20;11(2):890–920. doi: 10.1016/j.gendis.2023.06.017

Table 1.

Upstream regulators of IGF2BPs in cancers.

Upstream regulators IGF2BPs Regulatory mechanisms of upstream factors on IGF2BPs Effects on IGF2BPs expression References
miR-98–5p, miR-625, miR-196b, miR-494, miR-21, miR-372, miR-708, miR-506, miR-873 1 Inhibit IGF2BP1 expression by binding with its 3′UTR ↓ 43,44,46,53,55,56,58, 59, 60
miR-485–5p, miR-216b, miR-141, miR-188, miR-138 2 Inhibit IGF2BP2 expression by binding with its 3′UTR ↓ 45,52,54,61,62
miR-34a, miR-129-1, miR-486 3 Inhibit IGF2BP3 expression by binding to its 3′UTR ↓ 48,49,51
let-7 family 1/2/3 Bind to the 3′UTR ↓ 57,63,64,232
miR-200a 2/3 Target the 3′UTR of IGF2BP2/3 mRNA to down-regulate its expression ↓ 47
miR-1275 1/2/3 Inhibit IGF2BP1/2/3 expression by directly binding to their 3′UTR ↓ 50
lncRNA THOR 1 Promote the mRNA stabilization activities of IGF2BP1 ↑ 79
linc01134 1 Function as ceRNA to up-regulate IGF2BP1 via sponging miR-324–5p ↑ 71
lncRNA TRPM2-AS 1 Act as a microRNA sponge of miR-612 to up-regulate IGF2BP1 ↑ 72
lncRNA PCAT6 1 Function as ceRNA to up-regulate IGF2BP1 via sponging miR-513 ↑ 75
circBICD2 1 Regulate IGF2BP1 via miR-149–5p ↑ 69
lncRNA MALAT1 2 Competitively binding to miR-204 to up-regulate IGF2BP2 ↑ 66
lncRNA RHPN1-AS1 2 Act as a sponge for miR-596 to up-regulate IGF2BP2 ↑ 76
circCD44 2 Function as a sponge for miR-502–5p to up-regulate IGF2BP2 ↑ 73
HBV-pgRNA 3 Function as a sponge for miR-let-7e-5p to up-regulate IGF2BP3 ↑ 67
LINC00460 3 Function as a sponge for miR-320b to up-regulate IGF2BP3 ↑ 70
lncRNA KCNMB2-AS1 3 Function as a sponge for miR-130b-5p and miR-4294 to up-regulate IGF2BP3 ↑ 77
circIGHG 3 Bind to miR-142–5p and consequently elevated IGF2BP3 activity ↑ 68
circHIPK3 3 Promote IGF2BP3 expression via interacting with miR-654 ↑ 74
menin-histone methyltransferases 2 In a time-dependent manner ↑ 37
β-catenin 1 The nuclear translocation of β-catenin promotes IGF2BP1 transactivation ↑ 38
HMGA2 and HMGA2Tr 2 Promote the transcription of IGF2BP2 together with NF-κB ↑ 39
HNF4G 2 Bind to the promoter region of IGF2BP2 ↑ 42
MYC 3 Bind to the promoter of IGF2BP3 and increase its transcriptional activity ↑ 40
lncRNA DARS-AS1 3 Stabilize the mRNA of IGF2BP3 ↑ 78
mTOR 1/2/3 Phosphorylate IGF2BPs to promote their binding to downstream target mRNA \ 80, 81, 82
lncRNA LINRIS, SUMO1 2 Prevent IGF2BP2 degradation ↑ 85,87
circNEIL3, USP11 3 Prevent ubiquitination and degradation of IGF2BP3 ↑ 84,88
MKRN2 3 Mediate the ubiquitination of IGF2BP3 ↓ 83
circNDUFB2 1/2/3 Overexpression of CIRCNDUFB2 promotes the ubiquitination and degradation of IGF2BPs ↓ 86
estrogen receptor-β 3 Inhibit IGF2BP3 expression by repressing EGFR ↓ 41
YBX1 1/2/3 Important for promoting the recognition of the m6A-modified RNAs \ 90
RBRP, lncRNA-GHET1, lncRNA NEAT1, circXOP1 1 Promote the recognition and interaction with target mRNA \ 89,97,99,101
AURKA, lncRNA SNHG12, linc01305, lncRNA PCAT6, LINC01559, LINC00460, circITGB6, circNSUN2, circARHGAP29, circARHGAP12 2 Strengthen IGF2BP2 interaction with target mRNA \ 18,23,93,94,96,100,104, 105, 106, 107
HuR, BAG3, circ-0039,411, lncRNA DMDRMR, lncRNA CERS6-AS1, LINC00467, linc01305, hsa_circ_0003258 3 Strengthen IGF2BP3 interaction with target mRNA \ 95,98,102,103,106,108,184,233
PTPN13, lncRNA FGF13-AS1, lncRNA NBAT1, LINC00261, circPTPRA 1 Inhibit the interaction between IGF2BP1 and c-MYC mRNA \ 92,109,110,113,114
LINC01093 1 Inhibit the interaction between IGF2BP1 and GLI1 mRNA \ 112
circ-TNPO3 3 Act as a protein decoy for IGF2BP3 to regulate the MYC-SNAIL axis \ 111
ABCF1 mRNA 3 Act as a sponge to limit the interaction with ABCG2, MMP9, and CD44 \ 91