Table 3.

The mechanism of IGF2BPs in regulating different ncRNAs in cancers.

IGF2BPs	Cancer	ncRNAs	Mechanism of IGF2BPs in regulating ncRNAs	References
1	CRC	miR-183	Prevent miR-183-dependent degradation of β-TrCP1	120
1	Ovarian cancer	miR-155–5p, miR-22–3p, miR-140–3P	Prevent miRNA-dependent degradation of SIRT1	118
1	HCC, ovarian cancer, lung cancer	miR-23a-3p, miR-125a-5p	Serve as an m6A reader and impair miRNA-dependent degradation of SRF	11
1	Breast cancer	lncRNA UCA1	Recruit CCR4-NOT deadenylase complex to destabilize it	148
1	HCC	lncRNA HULC	Recruit CCR4-NOT deadenylase complex to destabilize it	147
1	HCC	circMAP3K4	Promote translation	149
2	TC, NSCLC	lncRNA MALAT1	Positive feedback may exist between IGF2BP2 and lncRNA MALAT1	66,145
2	PC	lncRNA DANCR	Serve as an m6A reader to promote stabilization	16
2	CRC	lncRNA ZFAS1	Serve as an m6A reader to promote stabilization	144
2	CRC	miR-195	Prevent miRNA-dependent degradation of RAF-1	121
2	Renal cancer	lncRNA DUXAP9	Serve as an m6A reader to promote stabilization	142
2	Prostate cancer	lncRNA PCAT6	Serve as an m6A reader to promote stabilization	96
2	Cervical cancer	circARHGAP12	Serve as an m6A reader to promote stabilization	107
3	NPC	lncRNA TINCR	Slow its decay	146
3	Breast cancer	miR-3614	Blockade of miR-3614 maturation	139
3	Cervical cancer	lncRNA KCNMB2-AS1	Serve as an m6A reader to promote stabilization	77
1/3	HCC	LINC01138	Promote it stabilization	143
1/2/3	Ovarian clear cell carcinoma/glioblastoma/some kinds of solid cancers and fibrosarcoma	let-7	Prevent miRNA-dependent degradation of let-7 target mRNA	116,117,119

CRC: colorectal cancer; HCC: hepatocellular carcinoma; NSCLC: non-small cell lung cancer; NPC: nasopharyngeal carcinoma; PC, pancreatic cancer; TC: thyroid cancer.