Table 1.
Patient demographics and clinical and radiologic findings. Unless otherwise specified, p values were calculated with Kruskal-Wallis test (quantitative variables) or Pearson’s Chi squared test (qualitative variables).
| MOGAD n = 63 |
AQP4+ NMOSD n = 37 |
MS n = 26 |
P-value | MOGAD vs. MS P-value |
MOGAD vs. AQP4+NMOSD P-value |
|
|---|---|---|---|---|---|---|
| Demographics/Clinical data | ||||||
| Sex, female (%) | 30 (48) | 32 (87) | 20 (77) | < 0.001 | 0.01 | < 0.001 |
| Median age at attack onset, years (range) | 27 (4-74) | 52 (17-77) | 39 (19-59) | < 0.001 | 0.01 | < 0.001 |
| Children, <18 years (%) | 18 (29) | 1 (3) | 0 (0) | <0.001 a | 0.001 a | 0.001 a |
| Ethnicity, Caucasian (%) | 55 (87) | 24 (65) | 26 (100) | < 0.001 | 0.06 | 0.008 |
| Median EDSS at nadir (range) | 6 (0-8) n = 62 |
6 (2-8.5) n = 33 |
2 (2-6) n = 24 |
<0.001 | <0.001 | 0.48 |
| Radiologic findings | ||||||
| Marked central canal T2-hyperintensity | 18/63 (29) | 13/37 (35) | 1/26 (4) | 0.007 a | 0.01 a | 0.493 |
| Median number of days from myelitis symptom onset to spinal cord MRI (range) | 10 (1-24) n =44 |
8 (1-28) n = 25 |
17.5 (3-28) n = 18 |
0.05 | 0.015 | 0.84 |
a
Fisher’s exact test.
n= denotes the denominator as some patients did not have sufficient documentation to provide all data