TABLE 1.
Demographic data of the study population.
| ME/CFS norm HRBP (n = 309) group 1 | ME/CFS POTS (n = 226) group 2 | Healthy controls norm HRBP (n = 34) group 3 | p‐value one‐way ANOVA with post hoc Tukey's test or Kruskal–Wallis H‐test with post hoc Dunn's test or chi‐squared or Mann–Whitney test | |
|---|---|---|---|---|
| Age (years) | 42 (11) | 34 (9) | 34 (14) | F(2, 566) = 42.73, p < 0.0001; 1 vs. 2: p < 0.0001; 1 vs. 3: p < 0.0001 |
| Height (cm) | 169 (7) | 172 (7) | 171 (5) | F(2, 566) = 10.35, p < 0.0001; 1 vs. 2: p < 0.0001 |
| Weight (kg) | 69 (60–80) | 66 (59–75) | 64 (62–78) | X2 (2) = 6.58, p = 0.04 |
| BSA (duBois m2) | 1.79 (1.69–1.93) | 1.77 (1.68–1.90) | 1.77 (1.70–1.90) | X2 (2) = 1.45, p = 0.48 |
| BMI (kg/m2) | 24 (21–28) | 22 (20–25) | 22 (21–26) | X2 (2) = 18.32, p = 0.0001; 1 vs. 2: p < 0.0001 |
| Disease Dur (yrs) | 12 (7–20.5) | 8.5 (4–14.25) | na | p < 0.0001 † |
| Severity* (1,2,3%) | 91/173/45 29/56/15% | 54/113/59 24/50/26% | na | p = 0.004 # |
Abbreviations: BMI, body mass index; BSA, body surface area; formula of Dubois; Dur, duration; HC, healthy controls; na, not applicable; Norm HRBP, normal heart rate and blood pressure response during tilt test; POTS, postural orthostatic tachycardia syndrome during tilt test.
#
Chi‐square test.
†
Mann–Whitney test.
*
ME severity criteria (Carruthers et al., 2011).