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. 2023 Jul 1;31(9):2651–2661. doi: 10.1016/j.ymthe.2023.06.018

Figure 3.

Figure 3

TFEB nuclear translocation is not induced in PiZ livers by TRPML1 gene transfer

(A) Immunohistochemistry for TFEB in livers of wild-type or PiZ mice injected with AAV-GFP or AAV-TRPML1 and harvested at 4 weeks post injection. Quantification of TFEB-positive nuclei in livers is shown (n = 3 per group). (B) Immunoblots for LAMP1, SQSTM1/p62, and LC3 in livers of wild-type and PiZ mice injected with AAV-TRPML1 or AAV-GFP controls and relative quantifications (n = 3–4 per group). Data are shown as mean ± standard error. Student’s t test: ∗p value < 0.05; ∗∗p value < 0.01. WT, wild-type.