Table 1.

Aggregate behavioral scoring system

Symptom	Severity score
	0	1	2
Mobility	as WT	reduced movement (extended freezing)	no spontaneous movement
Gait	as WT	waddling gate	more severe abnormalities (bunny hops, more severe waddling/diagonal gait, etc.)
Hindlimb clasping	legs splayed outwards	one or both hindlimbs drawn toward each other or body	both legs pulled in tightly touching each other or body
Tremor	No tremor	intermittent or mild tremor	continuous or intermittent violent tremor
Breathing	normal breathing	short periods of rapid breathing or pauses in breathing	very irregular breathing (gasping or panting)
General condition	clean shiny coat, clear eyes, normal stance	dull eyes, dull coat/ungroomed, somewhat hunched stance	crusted or narrowed eyes, piloerection, hunched posture