Table 1.

PPI network of core targets and their topologic parameters

Target Gene	Target Protein	BC	CC	Degree
SRC	Proto-oncogene tyrosine-protein kinase Src	0.20762006	0.48484848	28
MAPK1	Mitogen-activated protein kinase 1	0.17673147	0.47058824	24
HSP90AA1	Heat shock protein HSP 90-alpha	0.16977015	0.4549763	23
AKT1	RAC-alpha serine/threonine-protein kinase	0.11534838	0.42477876	20
PTPN11	Tyrosine-protein phosphatase non-receptor type 11	0.03679226	0.4137931	19
ESR1	Estrogen receptor	0.15340146	0.42290749	18
EGFR	Epidermal growth factor receptor	0.05024366	0.41201717	17
RHOA	Transforming protein RhoA	0.06401316	0.4137931	16
JAK2	Tyrosine-protein kinase JAK2	0.03546004	0.384	13
MAPK14	Mitogen-activated protein kinase 14	0.02429386	0.39669421	12
IL2	Interleukin-2	0.02505976	0.39669421	10
AR	Androgen receptor	0.04274218	0.40336134	10
MAPK8	Mitogen-activated protein kinase 8	0.04652714	0.37209302	10
IGF1	Insulin-like growth factor I	0.04262397	0.40336134	10
CASP3	Caspase-3	0.04499786	0.37065637	9
JAK3	Tyrosine-protein kinase JAK3	0.00369136	0.36781609	9
F2	Prothrombin	0.19405893	0.39834025	9
KDR	Vascular endothelial growth factor receptor 2	0.02863362	0.37795276	9
MDM2	E3 ubiquitin-protein ligase Mdm2	0.01775826	0.37065637	8
MET	Hepatocyte growth factor receptor	0.00948654	0.37065637	8
PPARA	Peroxisome proliferator-activated receptor alpha	0.10941735	0.38866397	8
NOS3	Nitric oxide synthase, endothelial	0.00361191	0.35820896	7
PDPK1	3-phosphoinositide-dependent protein kinase 1	0.02824207	0.37795276	7
HSPA1A	Heat shock 70 kDa protein 1A	0.0122306	0.37209302	7
CSK	Tyrosine-protein kinase CSK	0.01007009	0.36641221	7
NOS2	Nitric oxide synthase, inducible	0.0100451	0.37944664	6
TGFBR1	TGF-beta receptor type-1	0.03064952	0.32876712	6
MMP2	72 kDa type IV collagenase	0.05836368	0.36226415	6