Table 2.
KEGG pathway analysis
| KEGG ID | Term | Gene Number | P value | Gene ID |
|---|---|---|---|---|
| hsa04068 | FoxO signaling pathway | 17 | 3.23E-09 | TGFB2, PDPK1, PLK1, IGF1, MAPK14, SOD2, EGFR, TGFBR1, PIK3CG, TGFBR2, IGF1R, MAPK10, MAPK8, CDK2, MDM2, AKT1, MAPK1 |
| hsa04915 | Estrogen signaling pathway | 14 | 3.34E-08 | HSPA8, HSP90AA1, NOS3, SRC, MMP2, ESR1, MMP9, EGFR, PIK3CG, ESR2, AKT1, MAPK1, CALM1, HSPA1A |
| hsa04014 | Ras signaling pathway | 20 | 3.64E-08 | PLA2G2A, PTPN11, IGF1, RHOA, EGFR, PGF, PIK3CG, IGF1R, MAPK10, ZAP70, MAPK8, KIT, PLA2G10, KDR, AKT1, MAPK1, CALM1, MET, FGFR2, FGFR1 |
| hsa04151 | PI3K-Akt signaling pathway | 23 | 3.94E-07 | GSK3B, HSP90AA1, SYK, NOS3, PDPK1, IGF1, EGFR, IL2, PGF, PIK3CG, IGF1R, RHEB, KIT, CDK2, MDM2, KDR, AKT1, MAPK1, JAK2, JAK3, MET, FGFR2, FGFR1 |
| hsa04917 | Prolactin signaling pathway | 11 | 7.13E-07 | MAPK10, GSK3B, MAPK8, SRC, MAPK1, AKT1, JAK2, MAPK14, ESR1, ESR2, PIK3CG |
| hsa04015 | Rap1 signaling pathway | 17 | 1.80E-06 | SRC, IGF1, ITGAL, MAPK14, RHOA, EGFR, PGF, PIK3CG, IGF1R, KIT, KDR, AKT1, MAPK1, CALM1, MET, FGFR2, FGFR1 |
| hsa04931 | Insulin resistance | 12 | 5.23E-06 | MAPK10, GSK3B, PTPN1, MAPK8, PDPK1, NOS3, NR1H2, NR1H3, AKT1, PTPN11, PPARA, PIK3CG |
| hsa04722 | Neurotrophin signaling pathway | 12 | 1.45E-05 | MAPK10, GSK3B, MAPK8, PDPK1, MAPKAPK2, MAPK1, AKT1, PTPN11, CALM1, MAPK14, RHOA, PIK3CG |
| hsa04668 | TNF signaling pathway | 11 | 3.05E-05 | MAPK10, CASP7, MAPK8, CCL5, CASP3, MMP3, MAPK1, AKT1, MAPK14, MMP9, PIK3CG |
| hsa04380 | Osteoclast differentiation | 12 | 3.32E-05 | MAPK10, TGFB2, MAPK8, SYK, CTSK, MAPK1, AKT1, PPARG, MAPK14, TGFBR1, PIK3CG, TGFBR2 |
| hsa04610 | Complement and coagulation cascades | 9 | 4.16E-05 | F7, SERPINA1, C1S, F10, PLAU, C1R, PLAT, F2, F3 |
| hsa04370 | VEGF signaling pathway | 8 | 1.37E-04 | SRC, NOS3, MAPKAPK2, KDR, MAPK1, AKT1, MAPK14, PIK3CG |
| hsa04664 | Fc epsilon RI signaling pathway | 8 | 2.72E-04 | MAPK10, MAPK8, SYK, PDPK1, MAPK1, AKT1, MAPK14, PIK3CG |
| hsa04010 | MAPK signaling pathway | 15 | 2.78E-04 | HSPA8, TGFB2, MAPK14, EGFR, TGFBR1, TGFBR2, MAPK10, MAPK8, CASP3, MAPKAPK2, AKT1, MAPK1, FGFR2, HSPA1A, FGFR1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 11 | 2.94E-04 | GSK3B, MAPK1, AKT1, IGF1, JAK2, MAPK14, JAK3, FGFR2, PIK3CG, FGFR1, IGF1R |
| hsa04919 | Thyroid hormone signaling pathway | 10 | 3.02E-04 | GSK3B, THRA, PDPK1, RHEB, SRC, MDM2, MAPK1, AKT1, ESR1, PIK3CG |
| hsa04071 | Sphingolipid signaling pathway | 10 | 4.15E-04 | MAPK10, MAPK8, PDPK1, NOS3, MAPK1, AKT1, MAPK14, CTSD, RHOA, PIK3CG |
| hsa04660 | T cell receptor signaling pathway | 9 | 5.68E-04 | GSK3B, ZAP70, PDPK1, MAPK1, AKT1, MAPK14, RHOA, IL2, PIK3CG |
| hsa04910 | Insulin signaling pathway | 10 | 0.001143915 | MAPK10, GSK3B, PTPN1, MAPK8, PDPK1, RHEB, MAPK1, AKT1, CALM1, PIK3CG |
| hsa04012 | ErbB signaling pathway | 8 | 0.001219899 | MAPK10, GSK3B, MAPK8, SRC, MAPK1, AKT1, EGFR, PIK3CG |
| hsa04912 | GnRH signaling pathway | 8 | 0.001587681 | MAPK10, MAPK8, SRC, MMP2, MAPK1, CALM1, MAPK14, EGFR |
| hsa04066 | HIF-1 signaling pathway | 8 | 0.002162982 | NOS2, NOS3, MAPK1, AKT1, IGF1, EGFR, PIK3CG, IGF1R |
| hsa04152 | AMPK signaling pathway | 9 | 0.002189371 | CCNA2, PDPK1, RHEB, AKT1, PPARG, HMGCR, IGF1, PIK3CG, IGF1R |
| hsa04620 | Toll-like receptor signaling pathway | 8 | 0.003786019 | MAPK10, MAPK8, CCL5, CTSK, MAPK1, AKT1, MAPK14, PIK3CG |
| hsa04621 | NOD-like receptor signaling pathway | 6 | 0.003941611 | MAPK10, HSP90AA1, MAPK8, CCL5, MAPK1, MAPK14 |
| hsa04150 | mTOR signaling pathway | 6 | 0.004588605 | PDPK1, RHEB, MAPK1, AKT1, IGF1, PIK3CG |
| hsa04350 | TGF-beta signaling pathway | 7 | 0.004948262 | TGFB2, NOG, MAPK1, BMP7, RHOA, TGFBR1, TGFBR2 |
| hsa04650 | Natural killer cell mediated cytotoxicity | 8 | 0.008121692 | ZAP70, SYK, CASP3, ICAM2, MAPK1, PTPN11, ITGAL, PIK3CG |
| hsa04920 | Adipocytokine signaling pathway | 6 | 0.010130688 | MAPK10, MAPK8, AKT1, PTPN11, JAK2, PPARA |
| hsa04750 | Inflammatory mediator regulation of TRP channels | 7 | 0.010350527 | MAPK10, MAPK8, SRC, IGF1, CALM1, MAPK14, PIK3CG |
| hsa04611 | Platelet activation | 8 | 0.011319533 | SYK, SRC, NOS3, MAPK1, AKT1, MAPK14, RHOA, PIK3CG |
| hsa04024 | cAMP signaling pathway | 10 | 0.012409541 | MAPK10, MAPK8, PDE4D, PDE4B, MAPK1, AKT1, CALM1, PPARA, RHOA, PIK3CG |
| hsa04612 | Antigen processing and presentation | 6 | 0.014143102 | HSPA8, HSP90AA1, B2M, CTSS, CTSB, HSPA1A |
| hsa04670 | Leukocyte transendothelial migration | 7 | 0.021377856 | MMP2, PTPN11, ITGAL, MAPK14, MMP9, RHOA, PIK3CG |
| hsa04064 | NF-kappa B signaling pathway | 6 | 0.02403003 | ZAP70, CSNK2A1, SYK, PLAU, CSNK2B, XIAP |
| hsa04062 | Chemokine signaling pathway | 9 | 0.024240122 | GSK3B, SRC, CCL5, MAPK1, AKT1, JAK2, JAK3, RHOA, PIK3CG |
| hsa04210 | Apoptosis | 5 | 0.029248074 | CASP7, CASP3, XIAP, AKT1, PIK3CG |
| hsa03320 | PPAR signaling pathway | 5 | 0.03742122 | FABP4, PDPK1, NR1H3, PPARG, PPARA |
| hsa04662 | B cell receptor signaling pathway | 5 | 0.04102281 | GSK3B, SYK, MAPK1, AKT1, PIK3CG |
| hsa04810 | Regulation of actin cytoskeleton | 9 | 0.044933097 | SRC, MAPK1, ITGAL, F2, RHOA, EGFR, FGFR2, PIK3CG, FGFR1 |
| hsa04310 | Wnt signaling pathway | 7 | 0.046167362 | MAPK10, GSK3B, MAPK8, MMP7, CSNK2A1, CSNK2B, RHOA |