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Putative structural model of the CLIC1 protein in the soluble, reduced monomeric form. CLIC1 has an active-site cysteine residue (Cys24). The N-terminus and C-terminus of CLIC1 are both cytoplasmic. The N-terminus domain is on the right (helices h1, h2, and h3), while the all-helical C-terminus domain is on the left (helices h4-h9). CLIC1, chloride intracellular channel 1; PTM, putative transmembrane region.
