Figure 8.

Alternative clinical trial approaches. (A) Risk assessment–based eligibility criteria for enrichment. Green indicates low risk, yellow indicates intermediate risk, and red indicates high risk. (B) Adaptive enrichment recruitment based on interim analysis response. Dark blue indicates patients who might benefit from treatment A. Light blue indicates patients that might benefit from treatment B. All randomly assigned patients (light orange). (C) Randomized discontinuation study design. Dark blue indicates patients who improve with therapy, light blue indicates patients who are stable with treatment, and violet indicates patients who deteriorate with treatment. Reprinted by permission from Reference 174.