Table 2.
Changes in blood glucose, pancreatic beta cell function and insulin resistance over 48 weeks on dolutegravir in the study participants
| Time point | Fasting blood glucose | 2-hour OGTT glucose | Pancreatic beta cell function (HOMA %β) |
Insulin resistance (HOMA IR) |
|---|---|---|---|---|
| Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | |
| Baseline | 90.1 (87.6, 92.6) | 115.9 (108.8, 122.9) | 65.1 (50.6, 79.7) | 1.05 (0.54, 1.56) |
| Week 12 | 86.8 (84.8, 88.8) | 101.3 (96.4, 106.2) | 90.8 (78.5, 103.2) | 1.33 (1.04, 1.61) |
| Difference | -3.3 (-6.0, -0.5) | -14.6 (-22.1, -7.0) | 24.9 (6.3, 43.6) | 0.27 (-0.24, 0.79) |
| p-value | 0.020 | 0.0003 | 0.010 | 0.294 |
| Week 24 | 89.2 (87.3, 91.1) | |||
| Difference | -0.8 (-3.3, 1.6) | |||
| p-value | 0.497 | |||
| Week 36 | 91.2 (89.3, 93.1) | 110.4 (105.9, 114.9) | 75.1 (61.5, 88.6) | 1.27 (0.90, 1.64) |
| Difference | 1.2 (-1.7, 4.1) | -5.1 (-12.4, 2.1) | 8.8 (-13.2, 30.7) | 0.22 (-0.44, 0.87) |
| p-value | 0.414 | 0.163 | 0.427 | 0.511 |
| Week 48 | 90.5 (88.5, 92.4) | 73.6 (61.0, 86.1) | 1.19 (0.85, 1.53) | |
| Difference | 0.4 (-2.2, 3.1) | 6.7 (-13.4, 26.8) | 0.14 (-0.46, 0.733) | |
| p-value | 0.742 | 0.506 | 0.648 |
OGTT- oral glucose tolerance test, HOMA %β- Homeostatic modeling for pancreatic beta cell function, HOMA IR- Homeostatic modelling for insulin resistance, CI- confidence interval