Fig. 4.

L-arginine/nitric oxide module gene expression pattern organized in a correlation minimum spanning tree. L-ARG/NO component genes include protein methyltransferases (PRMT1 and PRMT5), nitric oxide synthase (NOS), arginases (ARG1 and ARG2), dimethylarginine dimethyl-aminohydrolases (DDAH1 and DDAH2). The edge length between the discriminant nodes is proportional to the univariate correlation between the two genes within the module. A Normal vs Stage I/II OC, B Stage I/II vs III/IV OC gene expression comparative analysis, the size and color of the discriminant nodes are proportional to the -log (p value) and fold of change respectively; C L-ARG/NO pathway key enzymes, enzyme substrates, and enzyme products