Table 2.
Pan-Keratin Immunostaining and Tumor Phenotype in Breast and Clear Cell Renal and Papillary Renal Cell Cancer.
| Pan-keratin IHC result | ||||||||
|---|---|---|---|---|---|---|---|---|
| n | negative (%) | weak (%) | moderate (%) | strong (%) | P | |||
| Breast carcinoma of no special type | Primary Tumor | pT1 | 547 | 0.5 | 0.5 | 0.0 | 98.9 | 0.0023 |
| pT2 | 400 | 0.0 | 1.0 | 1.5 | 97.5 | |||
| pT3-4 | 89 | 0.0 | 0.0 | 3.4 | 96.6 | |||
| Grade | G1 | 171 | 0.6 | 0.6 | 0.0 | 98.8 | 0.0005 | |
| G2 | 538 | 0.2 | 0.4 | 0.0 | 99.4 | |||
| G3 | 366 | 0.3 | 1.1 | 2.7 | 95.9 | |||
| Regional Lymph Nodes | pN0 | 444 | 0.0 | 0.7 | 0.9 | 98.4 | 0.7401 | |
| pN1 | 217 | 0.0 | 0.5 | 0.9 | 98.6 | |||
| pN2 | 72 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| pN3 | 50 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| HER2 status | negative | 840 | 0.4 | 0.6 | 1.1 | 98.0 | 0.5544 | |
| positive | 114 | 0.0 | 0.0 | 0.9 | 99.1 | |||
| ER status | negative | 198 | 0.5 | 1.5 | 4.5 | 93.4 | <0.0001 | |
| positive | 713 | 0.1 | 0.3 | 0.1 | 99.4 | |||
| PR status | negative | 381 | 0.3 | 0.8 | 2.6 | 96.3 | <0.0001 | |
| positive | 564 | 0.2 | 0.4 | 0.0 | 99.5 | |||
| Triple negative | no | 749 | 0.1 | 0.3 | 0.3 | 99.3 | <0.0001 | |
| yes | 133 | 0.8 | 2.3 | 6.0 | 91.0 | |||
| Clear cell renal cell carcinoma | ||||||||
| ISUP grade | 1 | 236 | 7.6 | 17.8 | 21.2 | 53.4 | 0.1907 | |
| 2 | 248 | 7.7 | 17.3 | 21.0 | 54.0 | |||
| 3 | 206 | 7.8 | 20.9 | 19.4 | 51.9 | |||
| 4 | 42 | 21.4 | 26.2 | 9.5 | 42.9 | |||
| Fuhrmann grade | 1 | 38 | 7.9 | 5.3 | 15.8 | 71.1 | 0.0049 | |
| 2 | 443 | 7.4 | 18.1 | 21.2 | 53.3 | |||
| 3 | 210 | 7.6 | 21.0 | 21.0 | 50.5 | |||
| 4 | 50 | 20.0 | 26.0 | 6.0 | 48.0 | |||
| Thoenes grade | 1 | 268 | 6.3 | 17.2 | 20.1 | 56.3 | 0.0183 | |
| 2 | 406 | 8.6 | 18.0 | 21.4 | 52.0 | |||
| 3 | 67 | 14.9 | 29.9 | 9.0 | 46.3 | |||
| UICC stage | 1 | 340 | 3.5 | 15.0 | 17.9 | 63.5 | 0.001 | |
| 2 | 35 | 8.6 | 8.6 | 22.9 | 60.0 | |||
| 3 | 91 | 14.3 | 24.2 | 17.6 | 44.0 | |||
| 4 | 74 | 13.5 | 14.9 | 21.6 | 50.0 | |||
| Primary Tumor | 1 | 446 | 4.9 | 17.0 | 17.9 | 60.1 | <0.0001 | |
| 2 | 76 | 10.5 | 19.7 | 26.3 | 43.4 | |||
| 3-4 | 214 | 15.0 | 22.4 | 21.0 | 41.6 | |||
| Regional Lymph Nodes | 0 | 127 | 9.4 | 22.0 | 22.0 | 46.5 | 0.0114 | |
| ≥1 | 18 | 16.7 | 0.0 | 11.1 | 72.2 | |||
| Distant Metastasis | 0 | 113 | 6.2 | 15.9 | 22.1 | 55.8 | 0.192 | |
| ≥1 | 76 | 15.8 | 14.5 | 22.4 | 47.4 | |||
| Papillary renal cell carcinoma | ||||||||
| ISUP grade | 1 | 40 | 0.0 | 0.0 | 2.5 | 97.5 | 0.933 | |
| 2 | 92 | 1.1 | 2.2 | 1.1 | 95.7 | |||
| 3 | 58 | 1.7 | 1.7 | 3.4 | 93.1 | |||
| 4 | 1 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| Fuhrmann grade | 1 | 2 | 0.0 | 0.0 | 0.0 | 100.0 | 0.9965 | |
| 2 | 130 | 0.8 | 1.5 | 1.5 | 96.2 | |||
| 3 | 56 | 1.8 | 1.8 | 3.6 | 92.9 | |||
| 4 | 3 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| Thoenes grade | 1 | 49 | 0.0 | 0.0 | 2.0 | 98.0 | 0.664 | |
| 2 | 133 | 1.5 | 2.3 | 2.3 | 94.0 | |||
| 3 | 9 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| UICC stage | 1 | 104 | 0.0 | 1.0 | 0.0 | 99.0 | 0.0062 | |
| 2 | 18 | 0.0 | 0.0 | 5.6 | 94.4 | |||
| 3 | 5 | 20.0 | 0.0 | 40.0 | 40.0 | |||
| 4 | 12 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| Primary Tumor | 1 | 133 | 0.0 | 0.8 | 0.0 | 99.2 | 0.0007 | |
| 2 | 37 | 2.7 | 2.7 | 2.7 | 91.9 | |||
| 3-4 | 15 | 6.7 | 6.7 | 20.0 | 66.7 | |||
| Regional Lymph Nodes | 0 | 19 | 0.0 | 0.0 | 5.3 | 94.7 | 0.423 | |
| ≥1 | 7 | 0.0 | 0.0 | 0.0 | 100.0 | |||
| Distant Metastasis | 0 | 27 | 0.0 | 0.0 | 3.7 | 96.3 | 0.4935 | |
| ≥1 | 7 | 0.0 | 0.0 | 0.0 | 100.0 | |||