Table 1.

Genetically modified mouse models with p.R122H mutant trypsinogen. Cela1, chymotrypsin-like elastase 1 gene. BAC, bacterial artificial chromosome. Note that T7R123H mice contain the p.R123H mutation, which is analogous to p.R122H in human trypsinogen.

Citation	Method	Promoter	Trypsinogen	Gene
Archer et al. 2006 [35]	transgenic	short rat Cela1 promoter	mouse anionic trypsinogen (isoform T8)	coding DNA
Selig et al. 2006 [37]	transgenic	short rat Cela1 promoter	human PRSS1	coding DNA
Athwal et al. 2014 [38]	transgenic	short rat Cela1 promoter	human PRSS1	coding DNA
Huang et al. 2020 [39]	transgenic	full-length mouse Cela1 gene	human PRSS1	coding DNA
Gui et al. 2020 [32]	transgenic	native trypsinogen promoter	human PRSS1	full-length genomic in BAC
Wang et al. 2022 [41]	transgenic	native trypsinogen promoter	human PRSS1	full-length genomic in BAC
This work T7R123H mice	knock-in	native trypsinogen promoter	mouse cationic trypsinogen (isoform T7)	native genomic locus