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. Author manuscript; available in PMC: 2024 Aug 9.
Published in final edited form as: Cell Host Microbe. 2023 Jul 28;31(8):1371–1385.e6. doi: 10.1016/j.chom.2023.07.003

Figure 7. Expression of the Akkermansia adhesin MucA rescues MB1 population structure and reduces MB1 inflammation.

Figure 7.

(A) Aeromonas MbpA and Akkermansia muciniphila MucA contain similar domain architectures but are secreted and regulated via distinct mechanisms (T1SS and T5aSS). The dashed boxed region indicates putative surface exposed domains, the pink bars approximate the location of each PbH1 domain as indicated by SMART analysis, and purple hexagons are the domains involved in retaining the respective adhesins at the cell surface. The size of each adhesin is scaled according to the amino acid length.

(B) Expression of MucA rescues population structure defects associated with MB1 in the intestine.

(D) Expression of MucA reduces intestinal inflammation associated with the MB1 evolved isolate. Neutrophil abundance was compared using an unpaired t test (N=22, each). Line and error bars represent median with 95% CI.