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. 2023 Sep 9;80(10):288. doi: 10.1007/s00018-023-04928-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effect of TGFβ1 pathway activation and inhibition on pathway enrichment of rat VEH- and EDC-MMSCs. A bubble chart of the gene set enrichment analysis (GSEA) (top) and enrichment plot (bottom) using the Hallmark MSigDB collection for A VEH-MMSCs treated with vehicle or TGFβ1, and B EDC-MMSCs treated with vehicle or TGFβ Receptor I inhibitor comparisons. Normalized enrichment score (NES) is a metric whose sign corresponds to which end of the dataset is enriched in the tested gene set. The arrows indicate enriched pathways related to NER (orange) and TGFβ (red) signaling