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. 2023 Sep 9;80(10):288. doi: 10.1007/s00018-023-04928-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Early life exposure to endocrine-disrupting chemicals reprograms rat MMSC and impaired their capacity to repair the DNA. Myometrial stem cells (MMSC) from Eker rats exposed to endocrine-disrupting chemicals (EDCs) in early life present lower levels of several members of nucleotide excision repair (NER) pathway, and overactivation of the TGFβ pathway which is also linked to changes in this DNA damage repair signaling. The reprogrammed MMSCs present impaired NER capacity, leading to increased genetic instability, arise of mutations, and their transformation into tumor-initiating stem cells, which would result in uterine tumorigenesis later in life. Created with BioRender.com