Table 2.

Over time development and controversies in definition of metabolically healthy/unhealthy overweight/obese

Wildman et al. [90]	BioSHaRE-EU Healthy Obese Project [56]		Lavie et al. [91]
	Less strict	Stricter
IFG/IGT/T2DM	FPG > 126 mg/dL	FPG > 110 mg/dL	FPG > 100 mg/dL
BP ≥ 130/85 mmHg	BP > 140/90 mmHg	BP > 130/85 mmHg	BP > 130/85 mmHg
TAG > 150 mg/dL
HDL < 40 (W) or < 35 (M) mg/dL
WC > 88 cm (W), > 102 cm (M)
HOMA-IR [92]
hsCRP
BMI > 25 or > 30 kg/m [2]	None (MHO) or ≥ 1 (MUO)		0–1 (MHO) or ≥ 1 (MUO)

IFG impaired fasting glucose, IGT impaired glucose tolerance, T2DM type 2 diabetes mellitus, BP blood pressure, TAG triglycerides, HDL high-density lipoprotein, WC waist circumference, BMI body mass index, CAD coronary artery disease, HOMA-IR homeostasis model assessment for insulin resistance, hsCRP high-sensitivity C-reactive protein, MHO metabolically healthy overweight/obese, MUO metabolically unhealthy overweight/obese