Table 2.
MCPyV status and clinicopathological characteristics of patients with OSCC
| Total (115 patients), [125 tumours] | MCPyV positive (24 patients), [28 tumours] | MCPyV negative (91 patients), [97 tumours] | P value | |||
|---|---|---|---|---|---|---|
| n | n | % | n | % | ||
| Sex | ||||||
| Male | 64 | 11 | 45.8 | 53 | 58.2 | 0.357 |
| Female | 51 | 13 | 54.2 | 38 | 41.8 | |
| Age | ||||||
| Mean ± SD (Range) | 71.9 ± 12.9 (37–97) | 71.5 ± 12.4 (37–88) | 73.4 ± 14.8 (37–97) | 0.529 | ||
| Smoking (Brinkman index)* | ||||||
| 0–400 | 67 | 18 | 75.0 | 49 | 57.6 | 0.353 |
| 401–1000 | 28 | 4 | 16.7 | 24 | 28.2 | |
| 1001–4000 | 14 | 2 | 8.3 | 12 | 14.1 | |
| Alcohol consumption** | ||||||
| None | 65 | 16 | 66.7 | 49 | 58.3 | 0.16 |
| A few times | 7 | 3 | 12.5 | 4 | 4.8 | |
| Every day | 36 | 5 | 20.8 | 31 | 36.9 | |
| Tumour site | ||||||
| Tongue | 44 [49] | 7 [9] | 29.2 [32.1] | 37 [40] | 40.7 [41.2] | 0.684 [0.602] |
| Lower gingiva | 31 [33] | 8 | 33.3 [28.6] | 23 [25] | 25.3 [25.8] | |
| Upper gingiva | 12 | 3 | 12.5 [10.7] | 9 | 9.9 [9.3] | |
| Floor of the mouth | 11 | 1 | 4.2 [3.6] | 10 | 11.0 [10.3] | |
| Cheek mucosa | 8 [10] | 2 [3] | 8.3 [10.7] | 6 [7] | 6.6 [7.2] | |
| Palate | 6 [7] | 2 [3] | 8.3 [10.7] | 4 | 4.4 [4.1] | |
| Lip | 3 | 1 | 4.2 [3.6] | 2 | 2.2 [2.1] | |
| T classification | ||||||
| 1 | 36 [41] | 8 [11] | 33.3 [39.3] | 28 [30] | 30.8 [30.9] | 0.344 [0.218] |
| 2 | 43 [46] | 12 [13] | 50.0 [46.4] | 31 [33] | 34.1 [34.0] | |
| 3 | 4 [5] | 0 | 0 | 4 [5] | 4.4 [5.2] | |
| 4 | 32 [33] | 4 | 16.7 [14.3] | 28 [29] | 30.8 [29.9] | |
| N classification | ||||||
| 0 | 75 [84] | 16 [20] | 66.7 [71.4] | 59 [64] | 64.8 [66.0] | 0.0324 [0.0489] |
| 1 | 12 [13] | 6 | 25.0 [21.4] | 6 [7] | 6.6 [7.2] | |
| 2 | 25 | 2 | 8.3 [7.2] | 23 | 25.3 [23.7] | |
| 3 | 3 | 0 | 0 | 3 | 3.3 [3.1] | |
| M classification | ||||||
| 0 | 114 [124] | 24 [28] | 100 [100] | 90 [96] | 98.9 [99.0] | 1 [1] |
| 1 | 1 | 0 | 0 | 1 | 1.1 [1.0] | |
| Stage | ||||||
| I | 30 [34] | 7 [9] | 29.2 [32.1] | 23 [25] | 25.3 [25.8] | 0.061 [0.0585] |
| II | 28 [31] | 7 [9] | 29.2 [32.1] | 21 [22] | 23.1 [22.7] | |
| III | 11 [13] | 5 | 20.8 [17.9] | 6 [8] | 6.6 [8.2] | |
| IV | 46 [47] | 5 | 20.8 [17.9] | 41 [42] | 45.1 [43.3] | |
| Differentiation | ||||||
| Poor | 4 | 1 | 4.2 [3.6] | 3 | 3.3 [3.1] | 0.792 [0.895] |
| Moderately | 16 | 4 | 16.7 [14.3] | 12 | 13.2 [12.4] | |
| Well | 95 [105] | 19 [23] | 79.2 [82.1] | 76 [82] | 83.5 [84.5] | |
| Treatment | ||||||
| Surgery | 105 [114] | 22 [26] | 91.7 [92.9] | 83 [88] | 91.2 [90.7] | 0.571 [0.442] |
| CRT | 4 [5] | 0 | 0 | 4 [5] | 4.4 [5.2] | |
| Palliative care | 6 | 2 | 8.3 [7.1] | 4 | 4.4 [4.1] | |
| The number of OSCC | ||||||
| Single OSCC | 109 | 18 | 75.0 [64.3] | 91 | 100 [93.8] | 0.0000 [0.0002] |
| Multiple OSCC | 6 [16] | 6 [10] | 25.0 [35.7] | 0 [6] | 0 [6.2] | |
Statistically significant P values are in bold (P < 0.05)
*n = 109 (Single: 103 patients, Multiple: 6 patients)
**n = 108 (Single: 102 patients, Multiple: 6 patients)