Table 3.
Comparison of clinicopathological characteristics for patients with single vs. multiple OSCCs
| Single OSCC (109 patients, 109 tumours) | Multiple OSCC (6 patients, 16 tumours) | P value | |||
|---|---|---|---|---|---|
| n | (%) | n | (%) | ||
| Sex | |||||
| Male | 62 | (56.9) | 2 | (33.3) | 0.404 |
| Female | 47 | (43.1) | 4 | (66.7) | |
| Age | |||||
| Mean ± SD (Range) | 71.8 ± 12.6 (37–97) | 74.7 ± 18.9 (37–87) | 0.596 | ||
| Smoking (Brinkman index)* | |||||
| 0–400 | 61 | (59.2) | 6 | (100) | 0.195 |
| 401–1000 | 28 | (27.2) | 0 | (0) | |
| 1001–4000 | 14 | (13.6) | 0 | (0) | |
| Alcohol consumption** | |||||
| None | 60 | (58.8) | 5 | (83.3) | 0.614 |
| A few times | 7 | (6.9) | 0 | (0) | |
| Every day | 35 | (34.3) | 1 | (16.7) | |
| Tumour site*** | |||||
| Tongue + Floor of the mouth | 55 | (50.5) | 5 | (31.25) | 0.0467 |
| Lower + Upper gingiva | 40 | (36.7) | 5 | (31.25) | |
| Others (Cheek mucosa + Palate + Lip) | 14 | (12.8) | 6 | (37.5) | |
| T classification*** | |||||
| 1 + 2 | 73 | (67.0) | 14 | (87.5) | 0.145 |
| 3 + 4 | 36 | (33.0) | 2 | (12.5) | |
| N classification*** | |||||
| 0 | 69 | (63.3) | 15 | (93.75) | 0.0199 |
| 1 + 2 + 3 | 40 | (36.7) | 1 | (6.25) | |
| M classification*** | |||||
| 0 | 108 | (99.1) | 16 | (100) | 1 |
| 1 | 1 | (0.9) | 0 | (0) | |
| Stage*** | |||||
| I + II | 52 | (47.7) | 13 | (81.25) | 0.0152 |
| III + IV | 57 | (52.3) | 3 | (18.75) | |
| Differentiation*** | |||||
| Poor | 4 | (3.7) | 0 | (0) | 1 |
| Moderately | 14 | (12.8) | 2 | (12.5) | |
| Well | 91 | (83.5) | 14 | (87.5) | |
| Treatment*** | |||||
| Surgery | 99 | (94.3) | 15 | (93.75) | 0.592 |
| CRT | 4 | (3.7) | 1 | (6.25) | |
| Palliative care | 6 | (5.5) | 0 | (0) | |
| Detection of MCPyV DNA*** | |||||
| Positive | 18 | (16.5) | 10 | (62.5) | 0.0002 |
| Negative | 91 | (83.5) | 6 | (37.5) | |
Statistically significant P values are in bold (P < 0.05)
*n = 109 (Single: 103 patients, Multiple: 6 patients)
**n = 108 (Single: 102 patients, Multiple: 6 patients)
***Tumour No. (Total 125 tumours)