Table 1.
Metabolic genes identified from “Mammalian Metabolic Enzyme Database” present in “Biological Process” of Gene Ontology in HD group.
| Gene symbol | Annotation | Roche Chart Sector | Roche Chart Subsector | Sigma Chart Substrate | Sigma Chart General Term | Signma MiniMap Term |
|---|---|---|---|---|---|---|
| Aadac | Arylacetamide deacetylase | Lipid Metabolism: Carotenoids and Isoprenoids; Lipid Metabolism: Fatty Acids; | Carotenoids; Fatty Acid Oxidation; | Lipids; Vitamins, Co-Enzymes, and Hormones; | Isoprenoids; Lipid biosynthesis; | Lipid Metabolism; |
| Products of Isoprene Metabolism; | ||||||
| Abat | 4-aminobutyrate aminotransferase, mitochondrial | Amino Acid Metabolism: Glutamate, Proline, Hydroxyproline; | Asparate Group of Amino Acids; | Amino Acids; | Amino acids; | Pyrimidine Metabolism; |
| Amino Acid Metabolism: Serine, Threonine, Cysteine, Methionine; | Glutamate Decarboxylation Pathway; | |||||
| Adcy7 | Adenylate cyclase type 7 | Carbohydrate Metabolism: Di-and Polysaccharides; | Polysaccharides; | Purines and Pyrimidines; | Purines; | |
| Aldh1a2 | Retinal dehydrogenase 2 | Amino Acid Metabolism: Glutamate, Proline, Hydroxyproline; | Anaplerotic Reactions; Carotenoids; | Amino Acids; Vitamins, | Amino acids; Isoprenoids; | Isoprene Metabolism; |
| Amino Acid Metabolism: Histidine; Amino Acid Metabolism: Lysine; Carbohydrate Metabolism: Acidic Carbohydrate Derivatives; | Glutamate Decarboxylation Pathway; | Co-Enzymes, and Hormones; | Products of Isoprene Metabolism; | |||
| Carbohydrate Metabolism: Glycolysis and Gluconeogenesis; | Histidine Metabolism; Lysine Metabolism; | Pyrimidine Metabolism; | ||||
| Carbohydrate Metabolism: Pyruvate Turnover; Lipid Metabolism: Carotenoids and Isoprenoids; | Mesaconate Pathway; Porphyrins; Zoosterols; | |||||
| Lipid Metabolism: Glyco- and Phospholipids; Steroid Metabolism: Cholesterol Synthesis; | ||||||
| Tetrapyrrole Metabolism: Porphyrins, Cobalamin; | ||||||
| Atp2b3 | Plasma membrane calcium-transporting ATPase 3 | Carbohydrates; | TCA Cycle in the Mitochondrial Matrix; | |||
| Cd38 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | Nucleotide Metabolism: NAD, NADP; | ||||
| Enpp4 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 isoform X6 | Lipid Metabolism: Sphingolipids; Nucleotide Metabolism: Pyrimidines; | Pyrimidine Biosynthesis; Pyrimidines; | Lipids; | Phospholipids; | |
| Hmox1 | Heme oxygenase 1 | Tetrapyrrole Metabolism: Heme, | Bile Pigments; | |||
| Cytochromes, Cholorphyll; | ||||||
| Impdh2 | Inosine-5’-monophosphate dehydrogenase 2 | Nucleotide Metabolism: Purines; | Purines and Pyrimidines; | Purines; | Purine Metabolism; | |
| Nos1 | Nitric oxide synthase, brain | Amino Acids; | Amino acids; | Deamination of Amino Acids: | ||
| The Urea Cycle; | ||||||
| Nos3 | Nitric oxide synthase, endothelial | Amino Acids; | Amino acids; | Deamination of Amino Acids: | ||
| The Urea Cycle; | ||||||
| Pde5a | cGMP-specific 3’,5’-cyclic phosphodiesterase | Carbohydrate Metabolism: Di-and Polysaccharides; | Polysaccharides; | Prostaglandins, Thromboxanes, | ||
| and Leucotrienes; | ||||||
| Pla2g10 | Group 10 secretory phospholipase A2 precursor | Lipid Metabolism: Fatty Acids; Lipid Metabolism: Glyco- and Phospholipids; | Fatty Acid Oxidation; Phosphatides; | Lipids; | Phospholipids; | Prostaglandins, Thromboxanes, |
| and Leucotrienes; | ||||||
| Pla2g5 | Calcium-dependent phospholipase A2 precursor | Lipid Metabolism: Fatty Acids; Lipid Metabolism: Glyco- and Phospholipids; | Fatty Acid Oxidation; Phosphatides; | Lipids; | Phospholipids; | Prostaglandins, Thromboxanes, |
| and Leucotrienes; | ||||||
| Ptgs1 | Prostaglandin G/H synthase 1 precursor | Lipids; | Lipid biosynthesis; | |||
| Tymp | Thymidine phosphorylase | Nucleotide Metabolism: Pyrimidines; | Pyrimidines; | Purines and Pyrimidines; | Pyrimidines; | Pyrimidine Metabolism; |