Table 3.

Pathway integration by Joint-Pathway Analysis of DEGs and metabolites of HD group with controls.

Pathways in HD group	Total	Raw p	Holm adjust	FDR	Impact	Matched features
Aminoacyl-tRNA biosynthesis	74	0.000376	0.0316	0.0316	0.27397	cpd:C00152; cpd:C00135; cpd:C00079; cpd:C00062; cpd:C00065; cpd:C00047; cpd:C00148; mmu:15115; mmu:104458; mmu:22321; mmu:85305; mmu:110960; mmu:67417
Arginine biosynthesis	27	0.004647	0.38569	0.11503	0.53846	cpd:C00062; cpd:C00077; mmu:18125; mmu:18126; mmu:18127; mmu:18416
Glycerophospholipid metabolism	86	0.004936	0.40475	0.11503	0.41176	cpd:C00670; mmu:210992; mmu:236899; mmu:18784; mmu:26565; mmu:665270; mmu:13139; mmu:331374; mmu:381925; mmu:14555; mmu:74596; mmu:66358
Purine metabolism	169	0.005478	0.44369	0.11503	0.65476	mmu:328099; mmu:108147; mmu:11564; mmu:67054; mmu:54611; mmu:11513; mmu:432530; mmu:215446; mmu:18103; mmu:11636; mmu:11639; mmu:229949; mmu:50773; mmu:23918; mmu:242202; mmu:16434; mmu:27369; mmu:66358; mmu:224794
Thiamine metabolism	14	0.008126	0.6501	0.13652	0.38462	mmu:18041; mmu:11636; mmu:11639; mmu:229949
Linoleic acid metabolism	17	0.016754	1	0.20215	0.375	mmu:230459; mmu:18784; mmu:26565; mmu:665270
Arginine and proline metabolism	78	0.017854	1	0.20215	0.37662	cpd:C00062; cpd:C00300; cpd:C00148; cpd:C00077; mmu:18125; mmu:18126; mmu:18127; mmu:20810; mmu:66194; mmu:69051
Synthesis and degradation of ketone bodies	10	0.019253	1	0.20215	0.77778	mmu:15360; mmu:208715; mmu:64059
Butanoate metabolism	29	0.028148	1	0.26272	0.46429	mmu:64059; mmu:15360; mmu:208715; mmu:268860; mmu:14415
alpha-Linolenic acid metabolism	22	0.040688	1	0.34178	0.19048	mmu:18784; mmu:26565; mmu:665270; mmu:56473
Glycerolipid metabolism	35	0.057552	1	0.43948	0.41176	mmu:16891; mmu:381925; mmu:225913; mmu:13139; mmu:331374

(“cpd” represents “KEGG ID” whereas “mmu” represents “Entrez ID” of DEGs).