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. 2023 Sep 9;14:5567. doi: 10.1038/s41467-023-41279-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overview of murine atrioventricular development, highlighting the endocardial-to-mesenchymal transition (EndMT) at E9.25-10.5 and the epicardial-to-mesenchymal transition (EpiMT) at E12.5. b UMAP visualization of 48,822 cells from E7.75-E9.25 hearts and E10.5-E12.5 AV canals. Cell types are denoted by colour and number in legend in panel d. c UMAP visualization of select gene expression for endothelial, epicardial, mesenchymal, and myocardial biomarkers. d Select differentially expressed genes in complete dataset, showing emergence of endothelial, epicardial, myocardial, and mesenchymal populations. AV atrioventricular, STM septum transversum mesenchyme. See also Supplementary Fig. 1 and Supplementary Data 1–2. Source Data are provided as a Source Data file.