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. 2023 Sep 9;14:5567. doi: 10.1038/s41467-023-41279-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Force-directed layouts and (b) a heatmap of 4633 epicardial cells displaying average epicardial and mesenchymal gene profiles. Overlap in gene profile expression suggests emergence of EMP during EpiMT. Immunostaining of Hic1^nLacZ/+ AV canals for SOX9, ERG, and TNNT2 at (c) E12.5 (n = 9) and (d) E14.5 (n = 6) shows co-expression of mesenchymal SOX9 and AV EPDC Hic1^nLacZ within AV sulcus, suggesting transition to mesenchyme (arrowheads). Scale bars: 100 µm, 25 µm in ROIs. AV atrioventricular, AVs AV sulcus, epi epicardium, mes mesenchyme. See also Supplementary Fig. 6 and Supplementary Data 2 and 4.