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. 2023 Sep 9;14:5554. doi: 10.1038/s41467-023-41306-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a CUT&Tag-seq experiment design: tdTomato⁺ nuclei were immobilized on magnetic beads and “Cleavage Under Targets and Tagmentation” was performed with antibodies against H3K4me3 or H3K27me3. Reads from amplified libraries were mapped on reference genome and putative NEUROD1 binding sites were identified in silico. Created with BioRender.com. b Among 112 downregulated genes in Neurod1ST, we found 66 genes containing elevated H3K27me3 peaks (Group 1). In cohort of 153 upregulated genes in Neurod1ST, we identified 28 genes (Group 2) with increased H3K27me3 peaks in Control compared to Neurod1ST. c Representative genes for both Group1 and 2 are presented as an UCSC genome browser output. NEUROD1 binding motifs identified in silico are often adjacent to the detected peak loci of gene promoters.