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. 2023 Sep 9;14:5554. doi: 10.1038/s41467-023-41306-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Our study reveals dysregulated transcriptome and altered histone methylation patterns in Neurod1ST endocrine cells. Compared to the Control islets of Langerhans, the Neurod1ST endocrine cells exhibit reduced expression of endocrine-related genes and enrichment of non-endocrine genes associated with the exocrine system and pancreatic ductal cells. These findings emphasize the critical role of NEUROD1 in governing gene networks that determine the commitment and terminal differentiation of endocrine cells in the pancreas. Created with BioRender.com.