Table 4.
Cox Model for the Composite Outcome of Cardiovascular Death and Rehospitalization for Cardiovascular Event (N=1742)
| Univariable | Multivariable | |||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age, y | 1.01 (0.98–1.03) | 0.62 | 1.01 (0.99–1.03) | 0.473 |
| Men | 1.31 (1.03–1.65) | 0.025 | 1.24 (0.98–1.58) | 0.078 |
| Previous CAD | 1.22 (0.97–1.55) | 0.092 | 1.03 (0.80–1.32) | 0.817 |
| Previous CHF | 1.18 (0.93–1.48) | 0.17 | ||
| Prior cardiac surgery | 2.24 (1.62–3.10) | <0.001 | 1.76 (1.25–2.49) | 0.001 |
| Diabetes | 1.17 (0.91–1.49) | 0.21 | ||
| Hypertension | 1.05 (0.78–1.41) | 0.74 | ||
| Dyslipidemia | 0.90 (0.72–1.13) | 0.38 | ||
| Chronic lung disease | 1.38 (1.04–1.83) | 0.024 | ||
| AF | 2.15 (1.64–2.82) | <0.001 | 1.93 (1.45–2.56) | <0.001 |
| NYHA class III/IV | 1.67 (1.33–2.10) | <0.001 | 1.44 (1.13–1.83) | 0.004 |
| STS PROM, % | 1.03 (1.02–1.05) | <0.001 | 1.02 (1.004–1.04) | 0.016 |
| AVAi, cm2/m2 | 1.83 (0.74–4.54) | 0.19 | ||
| AV mean PG, per 1 mm Hg | 0.98 (0.98–0.99) | <0.001 | ||
| LVEDV, mL | 1.01 (1.003–1.01) | <0.001 | ||
| LVSVi, mL/m2 | 0.99 (0.8–0.995) | 0.002 | ||
| LVEF <50% | 1.73 (1.29–2.31) | <0.001 | 1.22 (0.87–1.70) | 0.247 |
| Low‐flow: LVSVi <35 mL/m2 | 1.35 (1.03–1.78) | 0.029 | 0.87 (0.64–1.16) | 0.338 |
|
Low‐gradient mean PG <40 mm Hg |
1.90 (1.51–2.38) | <0.001 | 1.69 (1.33–2.15) | <0.001 |
AF indicates atrial fibrillation; AV, aortic valve; AVAi, aortic valve area index; CAD, coronary artery disease; CHF, congestive heart failure; HR, hazard ratio; LVEDV, left ventricular end‐diastolic volume; LVEF, left ventricular ejection fraction; LVSVi, left ventricular stroke volume index; NYHA, New York Heart Association; PG, pressure gradient; and STS PROM, Society of Thoracic Surgeons predicted risk of mortality.