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. 2023 Jul 25;12(15):e030603. doi: 10.1161/JAHA.123.030603

Figure 1. The association between clonal hematopoiesis and heart failure.

Figure 1

Mutations in hematopoietic stem and progenitor cells give rise to clones that expand over time (1). Factors stimulate clonal proliferation (2). Consequently, these mutated cells enter the blood stream and myocardium and cause atherosclerosis (3) or impair cardiac function (4). An inflammasome/interleukin 1/6‐mediated response (5) is central in clonal hematopoiesis‐induced heart failure (6). Heart failure could be a driver of clonal proliferation, as indicated by the dashed line. Solid lines are based on published results. CHIP indicates clonal hematopoiesis of indeterminate potential; IL‐1, interleukin‐1; IL‐6, interleukin‐6; LV, left ventricular; NLRP3, NLR family pyrin domain containing 3; and ROS, reactive oxygen species.