Figure 1. Psilocybin causes dramatic acute brain network changes.

Brain-wide connectivity change (Euclidian distance) was calculated across the cortex and subcortical structures and effects of condition were determined with a linear mixed effects (LME) model. a) Top: psilocybin-associated network change (LME model, t-statistic). Middle: methylphenidate-associated network stimulant. Bottom: day to day FC variability (random effect of day). b) Whole Brain network change magnitude (Euclidian distance between brain-wide connectivity matrices) reveals that psilocybin produces much larger change than methylphenidate, closer in magnitude to between person differences. Vertical bars and asterisks indicate significance (p<0.05) for post-hoc t-test between conditions. c) Change by system (resting-state network), based on individualized Infomap parcellation. Open circles represent individual subjects, bars represent average magnitude. *Disruption was significantly enriched within the default mode network based on rotation permutation testing. d) Psilocybin Network Change across the bilateral hippocampus, basal ganglia, and cerebellum (same color scale as panel a).