Figure 4. A persisting decrease in anterior hippocampal-DMN connectivity after psilocybin.

a) Group network change (relative to baseline) t-maps, left hippocampus: top=acute psilocybin, bottom = persisting (2 weeks after psilocybin. b) All subjects demonstrated a weakening of anterior hippocampal-cortical FC post-psilocybin (p=5.1e-5; linear mixed effects model accounting for head motion and subject ID). c) Connectivity from an anterior hippocampus seedmap at baseline, post-psilocybin and change for an exemplar (P3). The red border on the right-most brain illustrates individual-defined default mode network. A decrease in hippocampal FC with parietal and frontal components of the DMN is seen. d) Timecourse of anterior hippocampus - DMN for all participants/scans (participant colors as in panel b). A moving average is shown in black. e) schematic of hippocampal-cortical circuits, borrowed from Zheng et al., 2021.