Table 2.
Multivariate Cox analysis of choline and clinical outcomes in total PH patients
| Variable | HR | 95% CI | P |
|---|---|---|---|
| Choline | 1.934 | 1.034–3.619 | 0.039 |
| Age, years | 1.003 | 0.984–1.021 | 0.781 |
| NT-proBNP, pg/mL (categorical variable) | 0.755 | 0.421–1.353 | 0.345 |
| Creatinine, µM | 1.002 | 1.000-1.005 | 0.035 |
| PeakVO2, mL/min/kg | 0.880 | 0.805–0.962 | 0.008 |
| 6MWD, m | 1.001 | 0.421–1.353 | 0.724 |
Plasma choline levels were put into the model as a categorical variable bounded by 50th percentile (12.6 µM). PH: pulmonary hypertension; NT-proBNP: N-terminal pro-brain natriuretic peptide; 6MWD: 6-minute walk distance