Table 3.

Multivariate Cox analysis of choline and clinical outcomes in PAH subgroup

Variable	HR	95% CI	P
Choline * (time < 240 days)	0.894	0.194–4.114	0.886
Choline * (time ≥ 240 days)	2.395	1.072–5.352	0.033
Age, years	0.985	0.959–1.012	0.262
BMI, kg/m2	0.969	0.891–1.055	0.468
WHO-FC	1.516	0.717–3.207	0.277
Total cholesterol, mM	1.113	0.768–1.613	0.573
Triglycerides, mM	1.056	0.649–1.717	0.828
6MWD, m	0.998	0.994–1.002	0.286

Plasma choline levels were put into the model as a categorical variable bounded by 50th percentile (12.6 µM). PAH: pulmonary arterial hypertension; BMI: body mass index; WHO FC: world health organization function class; 6MWT: 6-minute walk distance